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PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression

Hohensee, Ina ; Chuang, Han-Ning ; Grottke, Astrid ; Werner, Stefan ; Schulte, Alexander ; Horn, Stefan ; Lamszus, Katrin ; Bartkowiak, Kai ; Witzel, Isabell ; Westphal, Manfred ; Matschke, Jakob ; Glatzel, Markus ; Jücker, Manfred ; Pukrop, Tobias ; Pantel, Klaus ; Wikman, Harriet


Despite improvement of therapeutic treatments for breast cancer, the development of brain metastases has become a major limitation to life expectancy for many patients. Brain metastases show very commonly alterations in EGFR and HER2 driven pathways, of which PTEN is an important regulator. Here, we analyzed PTEN expression in 111 tissue samples of breast cancer brain metastases (BCBM). Loss of ...


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