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PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression

Hohensee, Ina, Chuang, Han-Ning, Grottke, Astrid, Werner, Stefan, Schulte, Alexander, Horn, Stefan, Lamszus, Katrin, Bartkowiak, Kai, Witzel, Isabell, Westphal, Manfred, Matschke, Jakob , Glatzel, Markus , Jücker, Manfred, Pukrop, Tobias, Pantel, Klaus and Wikman, Harriet (2017) PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression. Oncotarget 8 (4).

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Other URL: http://doi.org/10.18632/oncotarget.14047


Abstract

Despite improvement of therapeutic treatments for breast cancer, the development of brain metastases has become a major limitation to life expectancy for many patients. Brain metastases show very commonly alterations in EGFR and HER2 driven pathways, of which PTEN is an important regulator. Here, we analyzed PTEN expression in 111 tissue samples of breast cancer brain metastases (BCBM). Loss of ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
10.18632/oncotarget.14047DOI
Keywords:CANCER-CELLS; GENETIC ALTERATIONS; TUMOR-CELLS; MICROGLIA; SURVIVAL; LOOP; AKT; IDENTIFICATION; EXTRAVASATION; COLONIZATION; brain metastases; breast cancer; PTEN; microenvironment; astrocytes
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38798
Owner only: item control page
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