Go to content
UR Home

LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma

Dräger, Julia, Simon-Keller, Katja , Pukrop, Tobias, Klemm, Florian, Wilting, Jörg , Sticht, Carsten, Dittmann, Kai, Schulz, Matthias, Leuschner, Ivo, Marx, Alexander and Hahn, Heidi (2017) LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma. Oncotarget 8 (2).

Full text not available from this repository.

at publisher (via DOI)

Other URL: http://doi.org/10.18632/oncotarget.13887


Abstract

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and show characteristics of skeletal muscle differentiation. The two major RMS subtypes in children are alveolar (ARMS) and embryonal RMS (ERMS). We demonstrate that approximately 50% of ARMS and ERMS overexpress the LEF1/TCF transcription factor LEF1 when compared to normal skeletal muscle and that LEF1 can restrain ...

plus


Export bibliographical data



Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
10.18632/oncotarget.13887DOI
Keywords:COLORECTAL-CANCER CELLS; BETA-CATENIN; EMBRYONAL RHABDOMYOSARCOMA; BREAST-CANCER; COLON-CANCER; EXPRESSION; GROWTH; DIFFERENTIATION; ACTIVATION; REPRESSION; RMS; LEF1/TCF; WNT/beta-catenin signaling
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38813
Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons