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The activity of nintedanib in an animal model of allogenic left lung transplantation resembling aspects of allograft rejection

von Süßkind-Schwendi, Marietta ; Boxhammer, Elke ; Hirt, Stephan W. ; Schreml, Stephan ; Schmid, Christof ; Wollin, Lutz ; Lehle, Karla



Abstract

Aim of the Study: The prevention and treatment of chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) remain unsatisfactory. Growth factors may play an important role in the development of CLAD. This study evaluated the effects of nintedanib, a receptor tyrosine kinase inhibitor, in the treatment of CLAD after experimental LTx. Materials and Methods: A rat model of left ...

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