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Neonatal Nav1.5 protein expression in normal adult human tissues and breast cancer

Yamaci, Rezan Fahrioglu, Fraser, Scott P., Battaloglu, Esra, Kaya, Handan, Erguler, Kamil, Foster, Christopher S. and Djamgoz, Mustafa B.A. (2017) Neonatal Nav1.5 protein expression in normal adult human tissues and breast cancer. Pathology - Research and Practice 213 (8), pp. 900-907.

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Other URL: http://doi.org/10.1016/j.prp.2017.06.003


Abstract

Expression of the neonatal splice variant of the voltage-gated sodium channel alpha-subunit (VGSC) subtype Nav1.5 (nNav1.5), encoded by the gene SCN5A, was shown earlier to be upregulated in human breast cancer (BCa), both in vitro and in vivo. Channel activity promoted BCa invasion of Matrigel (R) in vitro and metastasis in vivo. Consequently, expression of nNav1.5 has been proposed as a ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für experimentelle Medizin und Therapieverfahren
Identification Number:
ValueType
10.1016/j.prp.2017.06.003DOI
Keywords:GATED SODIUM-CHANNEL; HUMAN PROSTATE-CANCER; IN-VIVO; FUNCTIONAL EXPRESSION; ESTROGEN-RECEPTOR; MEMBRANE-ACTIVITY; EPITHELIAL-CELLS; TUMOR GROWTH; METASTASIS; INVASION; Breast cancer; Metastasis; Voltage-gated sodium channel; Neonatal Nav1.5; Estrogen receptor
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38861
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