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Ror2 Signaling and Its Relevance in Breast Cancer Progression

Bayerlová, Michaela ; Menck, Kerstin ; Klemm, Florian ; Wolff, Alexander ; Pukrop, Tobias ; Binder, Claudia ; Beißbarth, Tim ; Bleckmann, Annalen


Breast cancer is a heterogeneous disease and has been classified into five molecular subtypes based on gene expression profiles. Signaling processes linked to different breast cancer molecular subtypes and different clinical outcomes are still poorly understood. Aberrant regulation of Wnt signaling has been implicated in breast cancer progression. In particular Ror1/2 receptors and several other ...


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