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Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides

Wutz, D., Gluhacevic, D., Chakrabarti, A., Schmidtkunz, K., Robaa, D., Erdmann, F., Romier, C. , Sippl, W., Jung, M. and König, B. (2017) Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides. Organic & Biomolecular Chemistry 15 (22), pp. 4882-4896.

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Other URL: http://doi.org/10.1039/c7ob00976c


Abstract

Histone deacetylases (HDACs) play a crucial role in numerous biological processes and therefore are targeted in anticancer research and in the field of epigenetics. Dithienylethenes (DTEs) and fulgimides were functionalized with hydroxamic acids, which is a known moiety binding to zinc dependent HDACs, to gain photoswitchable HDAC inhibitors. The new DTE based inhibitors showed moderate ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Identification Number:
ValueType
10.1039/c7ob00976cDOI
Keywords:ALPHA-CHYMOTRYPSIN ACTIVITY; ENABLE OPTICAL CONTROL; BY-PRODUCT FORMATION; HDAC INHIBITORS; DIARYLETHENE DERIVATIVES; ENZYME-INHIBITORS; VISIBLE-LIGHT; AZOBENZENE; PHOTOSWITCH; RECEPTORS;
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38891
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