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Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation

Rampanelli, Elena , Orsó, Evelyn, Ochodnicky, Peter, Liebisch, Gerhard , Bakker, Pieter J., Claessen, Nike, Butter, Loes M., van den Bergh Weerman, Marius A., Florquin, Sandrine, Schmitz, Gerd and Leemans, Jaklien C. (2017) Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation. Scientific Reports 7 (1).

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Other URL: http://doi.org/10.1038/s41598-017-01994-9

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

The collateral effects of obesity/metabolic syndrome include inflammation and renal function decline. As renal disease in obesity can occur independently of hypertension and diabetes, other yet undefined causal pathological pathways must be present. Our study elucidate novel pathological pathways of metabolic renal injury through LDL-induced lipotoxicity and metainflammation. Our in vitro and in ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Identification Number:
ValueType
10.1038/s41598-017-01994-9DOI
Keywords:FATTY-ACID OXIDATION; HUMAN MACROPHAGES; MITOCHONDRIAL-FUNCTION; INSULIN-RESISTANCE; ADIPOSE-TISSUE; KIDNEY INJURY; E-LDL; SIRT1; DISEASE; STRESS;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38899
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