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Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation

Rampanelli, Elena ; Orsó, Evelyn ; Ochodnicky, Peter ; Liebisch, Gerhard ; Bakker, Pieter J. ; Claessen, Nike ; Butter, Loes M. ; van den Bergh Weerman, Marius A. ; Florquin, Sandrine ; Schmitz, Gerd ; Leemans, Jaklien C.



Abstract

The collateral effects of obesity/metabolic syndrome include inflammation and renal function decline. As renal disease in obesity can occur independently of hypertension and diabetes, other yet undefined causal pathological pathways must be present. Our study elucidate novel pathological pathways of metabolic renal injury through LDL-induced lipotoxicity and metainflammation. Our in vitro and in ...

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