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Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme

Wurm, Jan Philip ; Holdermann, Iris ; Overbeck, Jan H. ; Mayer, Philipp H. O. ; Sprangers, Remco



Abstract

Crystal structures of enzymes are indispensable to understanding their mechanisms on a molecular level. It, however, remains challenging to determine which structures are adopted in solution, especially for dynamic complexes. Here, we study the bilobed decapping enzyme Dcp2 that removes the 5' cap structure from eukaryotic mRNA and thereby efficiently terminates gene expression. The numerous Dcp2 ...

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