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Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme

Wurm, Jan Philip, Holdermann, Iris, Overbeck, Jan H., Mayer, Philipp H. O. and Sprangers, Remco (2017) Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme. Proceedings of the National Academy of Sciences 114 (23), pp. 6034-6039.

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Other URL: http://doi.org/10.1073/pnas.1704496114


Abstract

Crystal structures of enzymes are indispensable to understanding their mechanisms on a molecular level. It, however, remains challenging to determine which structures are adopted in solution, especially for dynamic complexes. Here, we study the bilobed decapping enzyme Dcp2 that removes the 5' cap structure from eukaryotic mRNA and thereby efficiently terminates gene expression. The numerous Dcp2 ...

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Item type:Article
Date:2017
Institutions:Physics > Institute of Theroretical Physics
Identification Number:
ValueType
10.1073/pnas.1704496114DOI
Keywords:ARCHAEAL EXOSOME; NMR-SPECTROSCOPY; STRUCTURAL BASIS; RNA DEGRADATION; CAP RECOGNITION; PROTEINS; BINDING; ACTIVATION; PROTEASOME; DCP1-DCP2; mRNA decapping; Dcp2; NMR spectroscopy; catalytic activity; protein dynamics
Dewey Decimal Classification:500 Science > 530 Physics
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38900
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