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IL-17-producing γδ T cells switch migratory patterns between resting and activated states

McKenzie, Duncan R. ; Kara, Ervin E. ; Bastow, Cameron R. ; Tyllis, Timona S. ; Fenix, Kevin A. ; Gregor, Carly E. ; Wilson, Jasmine J. ; Babb, Rachelle ; Paton, James C. ; Kallies, Axel ; Nutt, Stephen L. ; Brüstle, Anne ; Mack, Matthias ; Comerford, Iain ; McColl, Shaun R.


Interleukin 17-producing gamma delta T (gamma delta T17) cells have unconventional trafficking characteristics, residing in mucocutaneous tissues but also homing into inflamed tissues via circulation. Despite being fundamental to gamma delta T17-driven early protective immunity and exacerbation of autoimmunity and cancer, migratory cues controlling gamma delta T17 cell positioning in barrier ...


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