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Guide-independent DNA cleavage by archaeal Argonaute from Methanocaldococcus jannaschii

Zander, Adrian ; Willkomm, Sarah ; Ofer, Sapir ; van Wolferen, Marleen ; Egert, Luisa ; Buchmeier, Sabine ; Stöckl, Sarah ; Tinnefeld, Philip ; Schneider, Sabine ; Klingl, Andreas ; Albers, Sonja-Verena ; Werner, Finn ; Grohmann, Dina


Prokaryotic Argonaute proteins acquire guide strands derived from invading or mobile genetic elements, via an unknown pathway, to direct guide-dependent cleavage of foreign DNA. Here, we report that Argonaute from the archaeal organism Methanocaldococcus jannaschii (MjAgo) possesses two modes of action: the canonical guide-dependent endonuclease activity and a non-guided DNA endonuclease ...


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