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Guide-independent DNA cleavage by archaeal Argonaute from Methanocaldococcus jannaschii

Zander, Adrian, Willkomm, Sarah, Ofer, Sapir, van Wolferen, Marleen, Egert, Luisa, Buchmeier, Sabine, Stöckl, Sarah, Tinnefeld, Philip, Schneider, Sabine , Klingl, Andreas, Albers, Sonja-Verena, Werner, Finn and Grohmann, Dina (2017) Guide-independent DNA cleavage by archaeal Argonaute from Methanocaldococcus jannaschii. Nature Microbiology 2 (6).

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Other URL: http://doi.org/10.1038/nmicrobiol.2017.34


Abstract

Prokaryotic Argonaute proteins acquire guide strands derived from invading or mobile genetic elements, via an unknown pathway, to direct guide-dependent cleavage of foreign DNA. Here, we report that Argonaute from the archaeal organism Methanocaldococcus jannaschii (MjAgo) possesses two modes of action: the canonical guide-dependent endonuclease activity and a non-guided DNA endonuclease ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie > Prof. Dr. Dina Grohmann
Identification Number:
ValueType
10.1038/nmicrobiol.2017.34DOI
Keywords:STRUCTURAL BASIS; BACTERIAL ARGONAUTE; SILENCING COMPLEX; RNA INTERFERENCE; RECOGNITION; SULFOLOBUS; PROTEINS; GENUS;
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38913
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