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Augmenter of liver regeneration (ALR) exhibits a dual signaling impact on hepatic acute-phase response

Dayoub, Rania, Buerger, Leonhard, Ibrahim, Sara, Melter, Michael and Weiss, Thomas S. (2017) Augmenter of liver regeneration (ALR) exhibits a dual signaling impact on hepatic acute-phase response. Experimental and Molecular Pathology 102 (3), pp. 428-433.

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Other URL: http://doi.org/10.1016/j.yexmp.2017.05.011


Abstract

The acute-phase response (APR) is an inflammatory process triggered mainly by IL-6 in response to neoplasm, tissue injury, infection or inflammation. Signaling of IL-6 is transduced by activating STAT3 which rapidly results in production of acute-phase proteins (APPs) such as fibrinogen beta (FGB) and haptoglobin (HP). Augmenter of liver regeneration (ALR), a hepatotrophic factor supporting liver ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Kinder- und Jugendmedizin
Identification Number:
ValueType
10.1016/j.yexmp.2017.05.011DOI
Keywords:EPIDERMAL-GROWTH-FACTOR; NF-KAPPA-B; GAMMA-FIBRINOGEN GENE; HUMAN HEPATOCYTES; HEPATOTROPHIC FACTOR; IN-VITRO; EXPRESSION; INTERLEUKIN-6; INFLAMMATION; PROTEINS; Augmenter of liver regeneration; Inflammation; Acute phase; Haptoglobin; Fibrinogen beta; STAT3
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38917
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