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Analysis of platelet-derived extracellular vesicles in plateletpheresis concentrates: a multicenter study

Black, Anne ; Orsó, Evelyn ; Kelsch, Reinhard ; Pereira, Melanie ; Kamhieh-Milz, Julian ; Salama, Abdulgabar ; Fischer, Michael B. ; Meyer, Eduardo ; Frey, Beat M. ; Schmitz, Gerd


BACKGROUNDRoutine quantification of platelet-derived extracellular vesicles (PL-EVs) may be useful in the quality control (QC) of platelet concentrates (PCs). The aim of this multicenter study was to establish and validate a consensus protocol for the standardized PL-EV quantification using conventional flow cytometers. STUDY DESIGN AMD METHODSEighty-six PCs were investigated in five blood ...


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