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Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

Neudecker, Viola ; Haneklaus, Moritz ; Jensen, Owen ; Khailova, Ludmila ; Masterson, Joanne C. ; Tye, Hazel ; Biette, Kathryn ; Jedlicka, Paul ; Brodsky, Kelley S. ; Gerich, Mark E. ; Mack, Matthias ; Robertson, Avril A. B. ; Cooper, Matthew A. ; Furuta, Glenn T. ; Dinarello, Charles A. ; O’Neill, Luke A. ; Eltzschig, Holger K. ; Masters, Seth L. ; McNamee, Eóin N.



Abstract

MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel disease (IBD) is poorly defined. Here, we report that miR-223 limits intestinal inflammation by constraining the nlrp3 inflammasome. miR-223 was increased in intestinal biopsies from patients with active IBD and in preclinical ...

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