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Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C., Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S., Gerich, Mark E., Mack, Matthias, Robertson, Avril A.B. , Cooper, Matthew A. , Furuta, Glenn T., Dinarello, Charles A., O’Neill, Luke A. , Eltzschig, Holger K., Masters, Seth L. and McNamee, Eóin N. (2017) Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. The Journal of Experimental Medicine 214 (6), pp. 1737-1752.

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Other URL: http://doi.org/10.1084/jem.20160462


Abstract

MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel disease (IBD) is poorly defined. Here, we report that miR-223 limits intestinal inflammation by constraining the nlrp3 inflammasome. miR-223 was increased in intestinal biopsies from patients with active IBD and in preclinical ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1084/jem.20160462DOI
Keywords:BOWEL-DISEASE; MICRORNA EXPRESSION; ULCERATIVE-COLITIS; IN-VIVO; MICE; IL-1-BETA; CELLS; ACTIVATION; COLON; IL-1;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38941
Owner only: item control page
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