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Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts

Hose, Alexander J., Depner, Martin, Illi, Sabina, Lau, Susanne, Keil, Thomas, Wahn, Ulrich, Fuchs, Oliver, Pfefferle, Petra Ina, Schmaußer-Hechfellner, Elisabeth, Genuneit, Jon , Lauener, Roger, Karvonen, Anne M., Roduit, Caroline, Dalphin, Jean-Charles, Riedler, Josef, Pekkanen, Juha, von Mutius, Erika, Ege, Markus J. , Bauer, Carl Peter, Forster, Johannes, Zepp, Fred, Wahn, Volker, Schuster, Antje, Bergmann, Renate L., Bergmann, Karl E., Reich, Andreas, Grabenhenrich, Linus, Schaub, Bianca, Loss, Georg J., Renz, Harald, Kabesch, Michael, Roponen, Marjut , Hyvärinen, Anne, Tiittanen, Pekka, Remes, Sami, Braun-Fahrländer, Charlotte, Frei, Remo, Kaulek, Vincent, Dalphin, Marie-Laure, Doekes, Gert, Blümer, Nicole and Frey, Urs (2017) Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts. Journal of Allergy and Clinical Immunology 139 (6), 1935-1945.e12.

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Other URL: http://doi.org/10.1016/j.jaci.2016.08.046


Background: Phenotypes of childhood-onset asthma are characterized by distinct trajectories and functional features. For atopy, definition of phenotypes during childhood is less clear. Objective: We sought to define phenotypes of atopic sensitization over the first 6 years of life using a latent class analysis (LCA) integrating 3 dimensions of atopy: allergen specificity, time course, and levels ...


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Item type:Article
Institutions:Medicine > Lehrstuhl für Kinder- und Jugendmedizin
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Keywords:RESPIRATORY SYMPTOMS; INHALANT ALLERGENS; SKIN-TEST; SENSITIZATION; ASTHMA; CHILDHOOD; RISK; IGE; CHILDREN; LIFE; Atopy; IgE; sensitization; asthma; lung function; cytokines; severe atopy; atopic diseases; latent class analysis; unsupervised clustering; path analysis; epidemiology
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38948
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