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Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure

Sag, Can Martin, Schnelle, Moritz, Zhang, Juqian, Murdoch, Colin E. , Kossmann, Sabine, Protti, Andrea, Santos, Celio X.C., Sawyer, Greta, Zhang, Xiaohong, Mongue-Din, Heloise, Richards, Daniel A. , Brewer, Alison C., Prysyazhna, Oleksandra, Maier, Lars S., Wenzel, Philip, Eaton, Philip J. and Shah, Ajay M. (2017) Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure. Circulation 135 (22), pp. 2163-2177.

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Other URL: http://doi.org/10.1161/CIRCULATIONAHA.116.023877


Abstract

BACKGROUND: Hypertension caused by increased renin-angiotensin system activation is associated with elevated reactive oxygen species production. Previous studies implicate NADPH oxidase (Nox) proteins as important reactive oxygen species sources during renin-angiotensin system activation, with different Nox isoforms being potentially involved. Among these, Nox2 is expressed in multiple cell ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1161/CIRCULATIONAHA.116.023877DOI
Keywords:II-INDUCED HYPERTENSION; VASCULAR OXIDATIVE STRESS; ANGIOTENSIN-II; NADPH OXIDASE; TRANSGENIC MICE; SUPEROXIDE PRODUCTION; IN-VIVO; P47(PHOX); HYPERTROPHY; DYSFUNCTION; angiotensin II; blood pressure; mice; NADPH oxidase
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38988
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