Zusammenfassung
An enantioselective three-step synthesis of the GABA uptake inhibitor (S)-(+)-homo-beta-proline was developed. The basis for the synthesis was the enantioselective Cu-I-catalyzed cyclopropanation of N-Boc-pyrrole, a substrate that persistently has proved to be challenging in such transformations. The cyclopropanation can be performed on a 150 mmol scale, and the two subsequent steps (i.e., ...
Zusammenfassung
An enantioselective three-step synthesis of the GABA uptake inhibitor (S)-(+)-homo-beta-proline was developed. The basis for the synthesis was the enantioselective Cu-I-catalyzed cyclopropanation of N-Boc-pyrrole, a substrate that persistently has proved to be challenging in such transformations. The cyclopropanation can be performed on a 150 mmol scale, and the two subsequent steps (i.e., hydrogenation and in situ cyclopropane-opening/double-deprotection) toward the target molecule proceed smoothly in quantitative yield without loss of enantiopurity.
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