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Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection

Channappanavar, Rudragouda ; Fett, Craig ; Mack, Matthias ; Ten Eyck, Patrick P. ; Meyerholz, David K. ; Perlman, Stanley



Abstract

Pathogenic human coronaviruses (CoVs), such as the severe acute respiratory syndrome (SARS)-CoV and the Middle East respiratory syndrome-CoV, cause acute respiratory illness. Epidemiological data from the 2002-2003 SARS epidemic and recent Middle East respiratory syndrome outbreak indicate that there may be sex-dependent differences in disease outcomes. To investigate these differences, we ...

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