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Neuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthma

Lee, Yungling Leo ; Acevedo, Nathalie ; Ezer, Sini ; Kebede Merid, Simon ; Gaertner, Vincent D. ; Söderhäll, Cilla ; D’Amato, Mauro ; Kabesch, Michael ; Melén, Erik ; Kere, Juha ; Pulkkinen, Ville


Single nucleotide polymorphisms (SNPs) close to the gain-of-function substitution, Asn(107) Ile (rs324981, A>T), in Neuropeptide S Receptor 1 (NPSR1) have been associated with asthma. Furthermore, a functional SNP (rs4751440, G>C) in Neuropeptide S (NPS) encodes a Val(6)Leu substitution on the mature peptide that results in reduced bioactivity. We sought to examine the effects of different ...


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