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Flavin-containing enzymes as a source of reactive oxygen species in HEMA-induced apoptosis

Schweikl, Helmut ; Gallorini, Marialucia ; Forstner, Markus ; Petzel, Christine ; Bolay, Carola ; Hiller, Karl-Anton ; Cataldi, Amelia ; Krifka, Stephanie ; Buchalla, Wolfgang


Objective. Oxidative stress induced by compounds of dental composites like 2-hydroxyethyl methacrylate (HEMA) due to excess formation of reactive oxygen species (ROS) disturbs vital cell functions leading to apoptosis. The sources of ROS in cells exposed to resin monomers are unknown. The present study investigates functions of flavin-containing ROS and RNS (reactive nitrogen species) producing ...


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