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Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1

Rathinasamy, Anchana ; Domschke, Christoph ; Ge, Yingzi ; Böhm, Hans-Henning ; Dettling, Steffen ; Jansen, David ; Lasitschka, Felix ; Umansky, Ludmila ; Gräler, Markus H. ; Hartmann, Jennifer ; Herold-Mende, Christel ; Schuetz, Florian ; Beckhove, Philipp


Regulatory T cells (Treg) hamper anti-tumor T-cell responses resulting in reduced survival and failure of cancer immunotherapy. Among lymphoid organs, the bone marrow (BM) is a major site of Treg residence and recirculation. However, the process governing the emigration of Treg from BM into the circulation remains elusive. We here show that breast cancer patients harbour reduced Treg frequencies ...


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