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Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure

Dewenter, Matthias, Neef, Stefan, Vettel, Christiane, Lämmle, Simon, Beushausen, Christina, Zelarayan, Laura C. , Katz, Sylvia, von der Lieth, Albert, Meyer-Roxlau, Stefanie, Weber, Silvio, Wieland, Thomas , Sossalla, Samuel, Backs, Johannes, Brown, Joan H., Maier, Lars S. and El-Armouche, Ali (2017) Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure. Circulation: Heart Failure 10 (5).

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Other URL: http://doi.org/10.1161/CIRCHEARTFAILURE.117.003840


Abstract

Background Considerable evidence suggests that calcium/calmodulin-dependent protein kinase II (CaMKII) overactivity plays a crucial role in the pathophysiology of heart failure (HF), a condition characterized by excessive -adrenoceptor (-AR) stimulation. Recent studies indicate a significant cross talk between -AR signaling and CaMKII activation presenting CaMKII as a possible downstream mediator ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1161/CIRCHEARTFAILURE.117.003840DOI
Keywords:CARDIAC-HYPERTROPHY; MYOCARDIAL HYPERTROPHY; LAMBETH CONVENTIONS; PRESSURE-OVERLOAD; MOUSE MODEL; CAMKII; DELTA; ARRHYTHMIAS; OVEREXPRESSION; CARDIOMYOPATHY; beta-adrenergic blockers; calcium; calmodulin-dependent protein kinase type 2; heart failure
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39033
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