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Differential effects of anoctamins on intracellular calcium signals

Cabrita, Inês ; Benedetto, Roberta ; Fonseca, Ana ; Wanitchakool, Podchanart ; Sirianant, Lalida ; Skryabin, Boris V. ; Schenk, Laura K. ; Pavenstädt, Hermann ; Schreiber, Rainer ; Kunzelmann, Karl



Abstract

The Ca2+-activated Cl- channel TMEM16A[anoctamin(ANO)1] is homologous to yeast Ist2 and has been shown to tether the cortical endoplasmic reticulum(ER) to the plasma membrane. We therefore examined whether ANO1 and other members of the ANO family affect intracellular Ca2+ ([Ca2+](i)) signals. It is shown that expression of ANO1 augments Ca2+ store release upon stimulation of GPCRs, whereas ...

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