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Delayed histochemical alterations within the neurovascular unit due to transient focal cerebral ischemia and experimental treatment with neurotrophic factors

Borlongan, Cesar V. ; Michalski, Dominik ; Pitsch, Roman ; Pillai, Deepu R. ; Mages, Bianca ; Aleithe, Susanne ; Grosche, Jens ; Martens, Henrik ; Schlachetzki, Felix ; Härtig, Wolfgang


Current stroke therapy is focused on recanalizing strategies, but neuroprotective co-treatments are still lacking. Modern concepts of the ischemia-affected neurovascular unit (NVU) and surrounding penumbra emphasize the complexity during the transition from initial damaging to regenerative processes. While early treatment with neurotrophic factors was shown to result in lesion size reduction and ...


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