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Inhibition of mTORC2 component RICTOR impairs tumor growth in pancreatic cancer models

Schmidt, Katharina M., Hellerbrand, Claus, Ruemmele, Petra, Michalski, Christoph W., Kong, Bo, Kroemer, Alexander, Hackl, Christina, Schlitt, Hans J., Geissler, Edward K. and Lang, Sven A. (2017) Inhibition of mTORC2 component RICTOR impairs tumor growth in pancreatic cancer models. Oncotarget 8 (15).

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Other URL: http://doi.org/10.18632/oncotarget.15524


Abstract

Mammalian Target of Rapamycin complex 2 (mTORC2) and its regulatory component Rapamycin-insensitive companion of mTOR (RICTOR) are increasingly recognized as important players in human cancer development and progression. However, the role of RICTOR in human pancreatic ductal adenocarcinoma (PDAC) is unclear so far. Here, we sought to analyze the effects of RICTOR inhibition in human pancreatic ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Chirurgie
Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
10.18632/oncotarget.15524DOI
Keywords:HEPATOCELLULAR-CARCINOMA; MAMMALIAN TARGET; CELL-PROLIFERATION; COLORECTAL-CANCER; GASTRIC-CANCER; IN-VITRO; C-MYC; RAPAMYCIN; EXPRESSION; AKT; mTORC2/RICTOR; PDAC; AKT; HIF-1
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39091
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