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Peptide Paratope Mimics of the Broadly Neutralizing HIV-1 Antibody b12

Haußner, Christina, Damm, Dominik, Nirschl, Sandra, Rohrhofer, Anette, Schmidt, Barbara and Eichler, Jutta (2017) Peptide Paratope Mimics of the Broadly Neutralizing HIV-1 Antibody b12. ChemBioChem 18 (7), pp. 647-653.

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Other URL: http://doi.org/10.1002/cbic.201600621


Abstract

The broadly neutralizing HIV-1 antibody b12 recognizes the CD4 binding site of the HIV-1 envelope glycoprotein gp120 and efficiently neutralizes HIV-1 infections in vitro and in vivo. Based on the 3D structure of a b12-gp120 complex, we have designed an assembled peptide (b12-M) that presents the parts of the three heavy-chain complementarity-determining regions (CDRs) of b12, which contain the ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
10.1002/cbic.201600621DOI
Keywords:IMMUNODEFICIENCY-VIRUS; MONOCLONAL-ANTIBODY; IN-VITRO; ENVELOPE GLYCOPROTEINS; DESIGN; GP120; IMMUNOGENS; INFECTION; RESPONSES; BINDING; antibody mimics; gp120; HIV-1; immunochemistry; MAb b12; peptides
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39096
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