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Design of the effect of adaptive servo-ventilation on survival and cardiovascular hospital admissions in patients with heart failure and sleep apnoea: the ADVENT-HF trial

Lyons, Owen D. ; Floras, John S. ; Logan, Alexander G. ; Beanlands, Robert ; Cantolla, Joaquin Durán ; Fitzpatrick, Michael ; Fleetham, John ; John Kimoff, R. ; Leung, Richard S.T. ; Lorenzi Filho, Geraldo ; Mayer, Pierre ; Mielniczuk, Lisa ; Morrison, Debra L. ; Ryan, Clodagh M. ; Series, Frederic ; Tomlinson, George A. ; Woo, Anna ; Arzt, Michael ; Parthasarathy, Sairam ; Redolfi, Stefania ; Kasai, Takatoshi ; Parati, Gianfranco ; Delgado, Diego H. ; Bradley, T. Douglas


Introduction Both types of sleep-disordered breathing (SDB), obstructive and central sleep apnoea (OSA and CSA, respectively), are common in patients with heart failure and reduced ejection fraction (HFrEF). In such patients, SDB is associated with increased cardiovascular morbidity and mortality but it remains uncertain whether treating SDB by adaptive servo-ventilation (ASV) in such patients ...


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