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A role for astrocytes in cerebellar deficits in frataxin deficiency: Protection by insulin-like growth factor I

Franco, C, Genis, L, Navarro, JA, Perez-Domper, P, Fernandez, AM, Schneuwly, S and Torres Alemán, I (2017) A role for astrocytes in cerebellar deficits in frataxin deficiency: Protection by insulin-like growth factor I. Molecular and Cellular Neuroscience 80, pp. 100-110.

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Other URL: http://doi.org/10.1016/j.mcn.2017.02.008


Abstract

Inherited neurodegenerative diseases such as Friedreich's ataxia (FRDA), produced by deficiency of the mitochondrial chaperone frataxin (Fxn), shows specific neurological deficits involving different subset of neurons even though deficiency of Fxn is ubiquitous. Because astrocytes are involved in neurodegeneration, we analyzed whether they are also affected by frataxin deficiency and contribute ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly)
Identification Number:
ValueType
10.1016/j.mcn.2017.02.008DOI
Keywords:GAA TRIPLET-REPEAT; FRIEDREICH ATAXIA; GENE-EXPRESSION; TRANSGENIC MICE; MOUSE MODELS; NEURODEGENERATION; EXPANSION; CORTEX; CELLS; CALCINEURIN; Frataxin deficiency; Astrocytes; Brain development; Insulin-like growth factor I
Dewey Decimal Classification:500 Science > 590 Zoological sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39112
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