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Characteristics of donor-specific anti-HLA antibodies and outcome in renal transplant patients treated with a standardized induction regimen

Zecher, Daniel ; Bach, Christian ; Staudner, Christoph ; Böger, Carsten A. ; Bergler, Tobias ; Banas, Bernhard ; Spriewald, Bernd M.


Background. Pre-transplant donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) have been associated with antibody-mediated rejection (AMR) and early kidney allograft loss. Uncertainties remain regarding the general applicability of these findings and the optimal induction therapy in DSA-positive patients. Methods. Pre-transplant sera from 174 patients receiving a ...


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