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Death receptor 3 signaling enhances proliferation of human regulatory T cells

Bittner, Sebastian, Knoll, Gertrud and Ehrenschwender, Martin (2017) Death receptor 3 signaling enhances proliferation of human regulatory T cells. FEBS Letters 591 (8), pp. 1187-1195.

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Other URL: http://doi.org/10.1002/1873-3468.12632


Abstract

Exploiting regulatory T cells (Tregs) to control aberrant immune reactions is a promising therapeutic approach, but is hampered by their relative paucity. In mice, activation of death receptor 3 (DR3), a member of the TNF-receptor superfamily (TNFRSF), increases Treg frequency and efficiently controls exuberant immune activation. For human Tregs, neither DR3 expression nor potential functions ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
10.1002/1873-3468.12632DOI
Keywords:VERSUS-HOST-DISEASE; ALLERGIC LUNG INFLAMMATION; IFN-GAMMA PRODUCTION; TNF-LIKE LIGAND; MARROW TRANSPLANTATION; PERIPHERAL-BLOOD; TL1A; DR3; EXPRESSION; ACTIVATION; DR3; TL1A; TNFRSF25; TNFSF15; Treg
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39114
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