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The hedgehog-signaling pathway is repressed during the osteogenic differentiation of dental follicle cells

Morsczeck, C. ; Reck, A. ; Beck, H. C.



Abstract

Dental follicle stem cells (DFCs) are precursor cells of alveolar osteoblasts, and previous studies have shown that the growth factor bone morphogenetic protein (BMP)2 induces the osteogenic differentiation of DFCs. However, the molecular mechanism down-stream of the induction of the osteogenic differentiation by BMP2 remains elusive. We investigated therefore the phosphoproteome of DFCs after ...

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