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Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes

Rein-Fischboeck, Lisa ; Pohl, Rebekka ; Haberl, Elisabeth M. ; Zimny, Sebastian ; Neumann, Maximilian ; Eisinger, Kristina ; Weiss, Thomas S. ; Krautbauer, Sabrina ; Buechler, Christa



Abstract

Tubulin alpha 8 (TUBA8) is highly abundant in murine liver tumors suggesting a role in hepatocellular carcinoma (HCC). Non-alcoholic steatohepatitis (NASH) is a risk factor for HCC. In mice that are fed with a methionine-choline deficient diet for two weeks to induce advanced murine NASH, we do see increased hepatic levels of TUBA8 protein. In animals given a high-fat diet for 14 weeks or an ...

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