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Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes

Rein-Fischboeck, Lisa, Pohl, Rebekka, Haberl, Elisabeth M., Zimny, Sebastian, Neumann, Maximilian, Eisinger, Kristina, Weiss, Thomas S. , Krautbauer, Sabrina and Buechler, Christa (2017) Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes. Molecular and Cellular Biochemistry 428 (1-2), pp. 161-170.

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Other URL: http://doi.org/10.1007/s11010-016-2926-4


Abstract

Tubulin alpha 8 (TUBA8) is highly abundant in murine liver tumors suggesting a role in hepatocellular carcinoma (HCC). Non-alcoholic steatohepatitis (NASH) is a risk factor for HCC. In mice that are fed with a methionine-choline deficient diet for two weeks to induce advanced murine NASH, we do see increased hepatic levels of TUBA8 protein. In animals given a high-fat diet for 14 weeks or an ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
10.1007/s11010-016-2926-4DOI
Keywords:HEPATOCELLULAR-CARCINOMA; NONALCOHOLIC STEATOHEPATITIS; NUCLEAR RECEPTORS; LIVER-DISEASES; MICE; CAR; HEPATOCARCINOGENESIS; STEATOSIS; FIBROSIS; ORIGINS; Liver fibrosis; Fatty liver; Hepatocellular carcinoma; Inflammation
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39130
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