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Mutated olfactomedin 1 in the interphotoreceptor matrix of the mouse retina causes functional deficits and vulnerability to light damage

Koch, Marcus A. ; Rosenhammer, Bernd ; Paper, Walter ; Volz, Cornelia ; Braunger, Barbara M. ; Hausberger, Johanna ; Jägle, Herbert ; Tamm, Ernst R.


Olfactomedin 1 (OLFM1) is a secreted glycoprotein and member of the olfactomedin protein family, which is preferentially expressed in various areas throughout the central nervous system. To learn about the functional properties of OLFM1 in the eye, we investigated its localization in the mouse and pig eye. In addition, we analyzed the ocular phenotype of Olfm1 mutant mice in which 52 amino acids ...


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