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A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years

Volz, Martin ; Schaumburger, Jens ; Frick, Hubert ; Grifka, Joachim ; Anders, Sven


Purpose Autologous Matrix-Induced Chondrogenesis (AMIC(A (R))) utilizing a type I/III collagen membrane was compared with microfracture (MFx) alone in focal cartilage lesions of the knee at one, two and five years. Methods Forty-seven patients (aged 37 +/- 10 years, mean defect size 3.6 +/- 1.6 cm(2)) were randomized and treated either with MFx, with sutured or glued AMIC(A (R)) in a prospective ...


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