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Tumor-infiltrating B cells producing antitumor active immunoglobulins in resected HCC prolong patient survival

Brunner, Stefan M., Itzel, Timo, Rubner, Christoph, Kesselring, Rebecca, Griesshammer, Eva, Evert, Matthias, Teufel, Andreas, Schlitt, Hans J. and Fichtner-Feigl, Stefan (2017) Tumor-infiltrating B cells producing antitumor active immunoglobulins in resected HCC prolong patient survival. Oncotarget 8 (41).

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Other URL: http://doi.org/10.18632/oncotarget.20238


Abstract

Background & Aims: The immunological microenvironment of HCC influences patient outcome, however, the role of B cells remains unclear. This study investigated effects of local B-cell infiltration in HCC cohorts on patient survival and immunological and molecular tumor microenvironment. Results: Unsupervised gene expression analysis of full cancer transcriptomes (N=2158) revealed a highly ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Chirurgie
Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10.18632/oncotarget.20238DOI
Keywords:CD8(+) T-CELLS; HEPATOCELLULAR-CARCINOMA; FAVORABLE PROGNOSIS; MEMORY PHENOTYPE; LIVER-DISEASE; IMMUNOTHERAPY; CANCER; PATHWAY; B cell; immune infiltrate; tumor microenvironment; gene expression; immunoglobulin
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39167
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