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Tumor-infiltrating B cells producing antitumor active immunoglobulins in resected HCC prolong patient survival

Brunner, Stefan M. ; Itzel, Timo ; Rubner, Christoph ; Kesselring, Rebecca ; Griesshammer, Eva ; Evert, Matthias ; Teufel, Andreas ; Schlitt, Hans J. ; Fichtner-Feigl, Stefan


Background & Aims: The immunological microenvironment of HCC influences patient outcome, however, the role of B cells remains unclear. This study investigated effects of local B-cell infiltration in HCC cohorts on patient survival and immunological and molecular tumor microenvironment. Results: Unsupervised gene expression analysis of full cancer transcriptomes (N=2158) revealed a highly ...


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