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Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation

Cairns, Rose ; Alvarez-Guaita, Anna ; Martínez-Saludes, Inés ; Wason, Sundeep J. ; Hanh, Jacky ; Nagarajan, Shilpa R. ; Hosseini-Beheshti, Elham ; Monastyrskaya, Katia ; Hoy, Andrew J. ; Buechler, Christa ; Enrich, Carlos ; Rentero, Carles ; Grewal, Thomas


Annexin A6 (AnxA6) has been implicated in the regulation of endo-/exocytic pathways, cholesterol transport, and the formation of multifactorial signaling complexes in many different cell types. More recently, AnxA6 has also been linked to triglyceride storage in adipocytes. Here we investigated the potential role of AnxA6 in fatty acid (FA) induced lipid droplet (LD) formation in hepatocytes. ...


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