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A rapid liquid chromatography-tandem mass spectrometry for the quantification of Fosfomycin in plasma, urine, and aqueous fluids

El-Najjar, Nahed, Jantsch, Jonathan and Gessner, André (2017) A rapid liquid chromatography-tandem mass spectrometry for the quantification of Fosfomycin in plasma, urine, and aqueous fluids. Journal of Chromatography B 1061-1062, pp. 57-64.

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Other URL: http://doi.org/10.1016/j.jchromb.2017.06.046


Abstract

A simple and fast ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the analysis of Fosfomycin in different matrices (human plasma/urine, and aqueous fluid) has been established and validated. Sample cleanup consists, depending on the matrix used, on protein precipitation or dilution with methanol containing isotopically labeled Fosfomycin as internal ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
10.1016/j.jchromb.2017.06.046DOI
Keywords:CRITICALLY-ILL PATIENTS; CAPILLARY-ELECTROPHORESIS; GAS-CHROMATOGRAPHY; BIOLOGICAL-FLUIDS; VALIDATED METHOD; OLD ANTIBIOTICS; HPLC-MS/MS; SAMPLES; HUMANS; Antibiotics; Fosfomycin; LC MS/MS; Pharmacokinetic; Therapeutic drug monitoring
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39190
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