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Neurodevelopmental outcomes of extremely low birthweight infants randomised to different PCO 2 targets: the PHELBI follow-up study

Thome, Ulrich H ; Genzel-Boroviczeny, Orsolya ; Bohnhorst, Bettina ; Schmid, Manuel ; Fuchs, Hans ; Rohde, Oliver ; Avenarius, Stefan ; Topf, Hans-Georg ; Zimmermann, Andrea ; Faas, Dirk ; Timme, Katharina ; Kleinlein, Barbara ; Buxmann, Horst ; Schenk, Wilfried ; Segerer, Hugo ; Teig, Norbert ; Bläser, Annett ; Hentschel, Roland ; Heckmann, Matthias ; Schlösser, Rolf ; Peters, Jochen ; Rossi, Rainer ; Rascher, Wolfgang ; Böttger, Ralf ; Seidenberg, Jürgen ; Hansen, Gesine ; Zernickel, Maria ; Bode, Harald ; Dreyhaupt, Jens ; Muche, Rainer ; Hummler, Helmut D



Abstract

Background Tolerating higher partial pressures of carbon dioxide (PCO2) in mechanically ventilated extremely low birthweight infants to reduce ventilator-induced lung injury may have long-term neurodevelopmental side effects. This study analyses the results of neurodevelopmental follow-up of infants enrolled in a randomised multicentre trial. Methods Infants (n=359) between 400 and 1000 g birth ...

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