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Endothelial damage is aggravated in acute GvHD and could predict its development

Mir, E ; Palomo, M ; Rovira, M ; Pereira, A ; Escolar, G ; Penack, O ; Holler, E ; Carreras, E ; Diaz-Ricart, M



Abstract

The aim of the present study was to explore whether there is enhanced endothelial dysfunction in patients developing acute GvHD (aGvHD) after allogeneic hematopoietic cell transplantation (allo-HCT) and to identify biomarkers with predictive and/or diagnostic value. In in vitro experiments, endothelial cells (ECs) were exposed to serum from patients with (aGvHD, n = 31) and without (NoGvHD, n = ...

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