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Normal human immune cells are sensitive to telomerase inhibition by Brassica -derived 3,3-diindolylmethane,partly mediated via ERα/β-AP1 signaling

Herz, Corinna ; Tran, Hoai Thi Thu ; Landerer, Steffen ; Gaus, Johanna ; Schlotz, Nina ; Lehr, Lia ; Schäfer, Wolfgang R. ; Treeck, Oliver ; Odongo, Grace Akinyi ; Skatchkov, Ivan ; Lamy, Evelyn


Scope: Indole-3-carbinol (13C) and 3,3'-diindolylmethane (DIM) from Brassica plants are regarded as promising anticancer phytochemicals. The enzyme telomerase is a very attractive target for cancer therapeutics; in normal cells such as lymphocytes, it plays a decisive role for cell maintenance. The effect of 13C and DIM on telomerase in normal human immune cells (PBMC) was studied compared to ...


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