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Normal human immune cells are sensitive to telomerase inhibition by Brassica -derived 3,3-diindolylmethane,partly mediated via ERα/β-AP1 signaling

Herz, Corinna, Tran, Hoai Thi Thu, Landerer, Steffen, Gaus, Johanna, Schlotz, Nina, Lehr, Lia, Schäfer, Wolfgang R., Treeck, Oliver, Odongo, Grace Akinyi, Skatchkov, Ivan and Lamy, Evelyn (2017) Normal human immune cells are sensitive to telomerase inhibition by Brassica -derived 3,3-diindolylmethane,partly mediated via ERα/β-AP1 signaling. Molecular Nutrition & Food Research 61 (9), p. 1600524.

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Other URL: http://doi.org/10.1002/mnfr.201600524


Abstract

Scope: Indole-3-carbinol (13C) and 3,3'-diindolylmethane (DIM) from Brassica plants are regarded as promising anticancer phytochemicals. The enzyme telomerase is a very attractive target for cancer therapeutics; in normal cells such as lymphocytes, it plays a decisive role for cell maintenance. The effect of 13C and DIM on telomerase in normal human immune cells (PBMC) was studied compared to ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde)
Identification Number:
ValueType
10.1002/mnfr.201600524DOI
Keywords:BREAST-CANCER CELLS; GENE-EXPRESSION; PROSTATE-CANCER; DIETARY INDOLE-3-CARBINOL; LYMPHOCYTE DEVELOPMENT; ENDOMETRIAL CANCER; ESTROGEN-RECEPTORS; ANTICANCER AGENT; DOWN-REGULATION; HEPG2 CELLS; 3,3-diindolylmethane; ER-AP-1 signal transduction; Phytoestrogens; Safety of phytochemicals; Telomerase
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39216
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