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Hyperfractionated accelerated radiation therapy plus cetuximab plus cisplatin chemotherapy in locally advanced inoperable squamous cell carcinoma of the head and neck

Kuhnt, Thomas, Schreiber, Andreas, Pirnasch, Anett, Hautmann, Matthias G., Hass, Peter, Sieker, Frank P., Engenhart-Cabillic, Rita, Richter, Michael, Dellas, Kathrin and Dunst, Jürgen (2017) Hyperfractionated accelerated radiation therapy plus cetuximab plus cisplatin chemotherapy in locally advanced inoperable squamous cell carcinoma of the head and neck. Strahlentherapie und Onkologie 193 (9), pp. 733-741.

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Other URL: http://doi.org/10.1007/s00066-017-1145-6


Abstract

Background Cetuximab (CET) is a potent inhibitor of the epidermal growth factor receptor and has been shown to have activity in squamous cell carcinoma of the head and neck (SCCHN). We conducted a single-arm phase II trial of a combination therapy comprising cisplatin (CIS), CET and hyperfractionated accelerated radiotherapy (HART). Patients and methods Patients with UICC stage III or IVA/B, M0 ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Strahlentherapie
Identification Number:
ValueType
10.1007/s00066-017-1145-6DOI
Keywords:PHASE-II; HUMAN-PAPILLOMAVIRUS; CANCER-PATIENTS; RADIOTHERAPY; TRIAL; PACLITAXEL; CARBOPLATIN; COMBINATION; SURVIVAL; Chemoradiotherapy; Toxicity; Smoking; Survival; Mucositis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39225
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