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Prognostic factors and outcomes in metastatic uveal melanoma treated with programmed cell death-1 or combined PD-1/cytotoxic T-lymphocyte antigen-4 inhibition

Heppt, Markus V. ; Heinzerling, Lucie ; Kähler, Katharina C. ; Forschner, Andrea ; Kirchberger, Michael C. ; Loquai, Carmen ; Meissner, Markus ; Meier, Friedegund ; Terheyden, Patrick ; Schell, Beatrice ; Herbst, Rudolf ; Göppner, Daniela ; Kiecker, Felix ; Rafei-Shamsabadi, David ; Haferkamp, Sebastian ; Huber, Margit A. ; Utikal, Jochen ; Ziemer, Mirjana ; Bumeder, Irmgard ; Pfeiffer, Christiane ; Schäd, Susanne G. ; Schmid-Tannwald, Christoph ; Tietze, Julia K. ; Eigentler, Thomas K. ; Berking, Carola


Background: Uveal melanoma (UM) is an ocular malignancy with high potential for metastatic spread. In contrast to cutaneous melanoma, immunotherapy has not yet shown convincing efficacy in patients with UM. Combined immune checkpoint blockade with checkpoint programmed cell death-1 (PD-1) and checkpoint cytotoxic T-lymphocyte antigen-4 (CTLA-4) inhibition has not been systematically assessed for ...


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