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Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma

Schumacher, Sarah ; Bartenhagen, Christoph ; Hoffmann, Martin ; Will, Daniel ; Fischer, Johannes C ; Baldus, Stephan E ; Vay, Christian ; Fluegen, Georg ; Dizdar, Levent ; Vallböhmer, Daniel ; Klein, Christoph A ; Knoefel, Wolfram T ; Stoecklein, Nikolas H ; Möhlendick, Birte


Background: Chromosomal instability (CIN) has repeatedly been identified as a prognostic marker. Here we evaluated the percentage of aberrant genome per cell (PAG) as a measure of CIN in single disseminated tumour cells (DTC) isolated from patients with operable oesophageal adenocarcinoma (EAC), to assess the impact of CINhigh DTCs on prognosis. Methods: We isolated CK18(positive) DTCs from bone ...


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