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Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy

Borchert, Thomas ; Hübscher, Daniela ; Guessoum, Celina I. ; Lam, Tuan-Dinh D. ; Ghadri, Jelena R. ; Schellinger, Isabel N. ; Tiburcy, Malte ; Liaw, Norman Y. ; Li, Yun ; Haas, Jan ; Sossalla, Samuel ; Huber, Mia A. ; Cyganek, Lukas ; Jacobshagen, Claudius ; Dressel, Ralf ; Raaz, Uwe ; Nikolaev, Viacheslav O. ; Guan, Kaomei ; Thiele, Holger ; Meder, Benjamin ; Wollnik, Bernd ; Zimmermann, Wolfram-Hubertus ; Lüscher, Thomas F. ; Hasenfuss, Gerd ; Templin, Christian ; Streckfuss-Bömeke, Katrin


BACKGROUND Takotsubo syndrome (TTS) is characterized by an acute left ventricular dysfunction and is associated with life-threating complications in the acute phase. The underlying disease mechanism in TTS is still unknown. A genetic basis has been suggested to be involved in the pathogenesis. OBJECTIVES The aims of the study were to establish an in vitro induced pluripotent stem cell (iPSC) ...


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