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Retinoschisin is linked to retinal Na/K-ATPase signaling and localization

Plössl, Karolina, Royer, Melanie, Bernklau, Sarah, Tavraz, Neslihan N., Friedrich, Thomas, Wild, Jens, Weber, Bernhard H. F. , Friedrich, Ulrike and Heldin, Carl-Henrik (2017) Retinoschisin is linked to retinal Na/K-ATPase signaling and localization. Molecular Biology of the Cell 28 (16), pp. 2178-2189.

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Other URL: http://doi.org/10.1091/mbc.E17-01-0064


Abstract

Mutations in the RS1 gene cause X-linked juvenile retinoschisis (XLRS), a hereditary retinal dystrophy. We recently showed that retinoschisin, the protein encoded by RS1, regulates ERK signaling and apoptosis in retinal cells. In this study, we explored an influence of retinoschisin on the functionality of the Na/K-ATPase, its interaction partner at retinal plasma membranes. We show that ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Humangenetik
Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
10.1091/mbc.E17-01-0064DOI
Keywords:NA+/K+-ATPASE; JUVENILE RETINOSCHISIS; SODIUM-PUMP; ANKYRIN-B; K-ATPASE; NA,K-ATPASE ACTIVITY; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; BIPOLAR CELLS; MAP KINASE;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39314
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