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Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery

Gertler, Ralph , Gruber, Michael, Grassin-Delyle, Stanislas, Urien, Saïk, Martin, Klaus, Tassani-Prell, Peter, Braun, Siegmund, Burg, Simon and Wiesner, Gunther (2017) Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery. British Journal of Clinical Pharmacology 83 (8), pp. 1745-1757.

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Other URL: http://doi.org/10.1111/bcp.13274


AimTranexamic acid (TXA) continues to be one of the antifibrinolytics of choice during paediatric cardiac surgery. However, in infants less than 1year of age, the optimal dosing based on pharmacokinetic (PK) considerations is still under discussion. MethodsForty-three children less than 1year of age were enrolled, of whom 37 required the use of cardiopulmonary bypass (CPB) and six were operated ...


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Item type:Article
Institutions:Medicine > Lehrstuhl für Anästhesiologie
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Keywords:CARDIOPULMONARY BYPASS; POPULATION PHARMACOKINETICS; CHILDREN; ADULTS; SEIZURES; FIBRINOLYSIS; PARAMETERS; MODELS; tranexamic acid; antifibrinolytic agents; pharmacokinetics; cardiac surgical procedures; congenital heart defects
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39323
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