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Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity

Neef, Stefan ; Heijman, Jordi ; Otte, Kristian ; Dewenter, Matthias ; Saadatmand, Ali R. ; Meyer-Roxlau, Stefanie ; Antos, Christopher L. ; Backs, Johannes ; Dobrev, Dobromir ; Wagner, Michael ; Maier, Lars S. ; El-Armouche, Ali



Abstract

Inhibitor-1 (I-1) modulates protein phosphatase 1 (PP1) activity and thereby counteracts the phosphorylation by kinases. I-1 is downregulated and deactivated in failing hearts, but whether its role is beneficial or detrimental remains controversial, and opposing therapeutic strategies have been proposed. Overactivity of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with ...

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