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Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity

Neef, Stefan, Heijman, Jordi , Otte, Kristian, Dewenter, Matthias, Saadatmand, Ali R., Meyer-Roxlau, Stefanie, Antos, Christopher L., Backs, Johannes, Dobrev, Dobromir, Wagner, Michael, Maier, Lars S. and El-Armouche, Ali (2017) Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity. Naunyn-Schmiedeberg's Archives of Pharmacology 390 (8), pp. 857-862.

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Other URL: http://doi.org/10.1007/s00210-017-1376-1


Abstract

Inhibitor-1 (I-1) modulates protein phosphatase 1 (PP1) activity and thereby counteracts the phosphorylation by kinases. I-1 is downregulated and deactivated in failing hearts, but whether its role is beneficial or detrimental remains controversial, and opposing therapeutic strategies have been proposed. Overactivity of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1007/s00210-017-1376-1DOI
Keywords:PROTEIN PHOSPHATASE-1 INHIBITOR-1; MYOCARDIAL HYPERTROPHY; HEART-FAILURE; MYOCYTES; Inhibitor-1; Ca2+/calmodulin-dependent protein kinase II; Protein phosphatase 1; Ryanodine receptor
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39324
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