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Prolotherapy Induces an Inflammatory Response in Human Tenocytes In Vitro

Ekwueme, Emmanuel C. ; Mohiuddin, Mahir ; Yarborough, Jazmin A. ; Brolinson, P. Gunnar ; Docheva, Denitsa ; Fernandes, Hugo A. M. ; Freeman, Joseph W.


Proliferative therapy, or prolotherapy, is a controversial treatment method for many connective tissue injuries and disorders. It involves the injection of a proliferant, or irritant solution, into the site of injury, which causes small-scale cell death. This therapeutic trauma is theorized to initiate the body's wound-healing cascade, perhaps leading to tissue repair. The immediate effects of ...


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