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Haematological malignancies following temozolomide treatment for paediatric high-grade glioma

Karremann, Michael ; Krämer, Nadja ; Hoffmann, Marion ; Wiese, Maria ; Beilken, Andreas ; Corbacioglu, Selim ; Dilloo, Dagmar ; Driever, Pablo Hernáiz ; Scheurlen, Wolfram ; Kulozik, Andreas ; Gielen, Gerrit H. ; von Bueren, André O. ; Dürken, Matthias ; Kramm, Christof M.



Abstract

Background: Temozolomide (TMZ) is widely used in high-grade glioma (HGG). There is a major concern of treatment-induced secondary haematological malignancies (SHMs). Due to the poor overall survival of HGG patients, the true incidence is yet elusive. Thus, the aim of this study was to determine the risk of SHMs following TMZ in paediatric HGG. Methods: We analysed 487 patients from the HIT-HGG ...

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