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Individual differences in stress vulnerability: The role of gut pathobionts in stress-induced colitis

Langgartner, Dominik ; Peterlik, Daniel ; Foertsch, Sandra ; Füchsl, Andrea M. ; Brokmann, Petra ; Flor, Peter J. ; Shen, Zeli ; Fox, James G. ; Uschold-Schmidt, Nicole ; Lowry, Christopher A. ; Reber, Stefan O.



Abstract

Chronic subordinate colony housing (CSC), an established mouse model for chronic psychosocial stress, promotes a microbial signature of gut inflammation, characterized by expansion of Proteobacteria, specifically Helicobacter spp., in association with colitis development. However, whether the presence of Helicobacter spp. during CSC is critically required for colitis development is unknown. ...

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