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Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells

Katoh, Masaru, Kishimoto, Yasuzumi, Ohkawara, Bisei, Sakai, Tadahiro, Ito, Mikako, Masuda, Akio, Ishiguro, Naoki, Shukunami, Chisa, Docheva, Denitsa and Ohno, Kinji (2017) Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells. PLOS ONE 12 (7), e0182051.

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Other URL: http://doi.org/10.1371/journal.pone.0182051

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Abstract

After tendon injuries, biomechanical properties of the injured tendon are not fully recovered in most cases. Modulation of signaling pathways, which are involved in tendon development and tendon repair, is one of attractive modalities to facilitate proper regeneration of the injured tendon. The roles of TGF-beta signaling in tendon homeostasis and tendon development have been elucidated. In ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Unfallchirurgie
Identification Number:
ValueType
10.1371/journal.pone.0182051DOI
Keywords:MESENCHYMAL STEM-CELLS; TGF-BETA; GROWTH-FACTORS; FLEXOR TENDON; IN-VIVO; PROGENITOR CELLS; GENE-EXPRESSION; TENOMODULIN; SCLERAXIS; DIFFERENTIATION;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39348
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