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Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells

Katoh, Masaru ; Kishimoto, Yasuzumi ; Ohkawara, Bisei ; Sakai, Tadahiro ; Ito, Mikako ; Masuda, Akio ; Ishiguro, Naoki ; Shukunami, Chisa ; Docheva, Denitsa ; Ohno, Kinji



Abstract

After tendon injuries, biomechanical properties of the injured tendon are not fully recovered in most cases. Modulation of signaling pathways, which are involved in tendon development and tendon repair, is one of attractive modalities to facilitate proper regeneration of the injured tendon. The roles of TGF-beta signaling in tendon homeostasis and tendon development have been elucidated. In ...

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